Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL10453278 | 0.97 | CYP1A2 (0.39) | CYP1A2LMNACYP2D6EPHX1HPGD | |
| Propionic Acid SCHEMBL19813178 | 0.92 | FFAR3 (0.50) | CYP1A2LMNACYP2D6EPHX1HPGD | |
| Cyclohexane SCHEMBL28777359 | 0.92 | CYP1A2 (0.41) | CYP1A2LMNACYP2D6EPHX1HPGD | |
| Acetic Acid SCHEMBL2485175 | 0.92 | CYP1A2 (0.41) | CYP1A2LMNACYP2D6EPHX1HPGD | |
| Bicarbonate SCHEMBL2862271 | 0.92 | ALOX5 (0.38) | CYP1A2LMNACYP2D6EPHX1ALOX5 | |
| Acetone SCHEMBL28163399 | 0.90 | CYP1A2 (0.42) | CYP1A2EPHX1HPGDKMT2AALOX5 | |
| Acetic Acid SCHEMBL27585871 | 0.90 | CYP1A2 (0.37) | CYP1A2LMNACYP2D6EPHX1HPGD | |
| Urea SCHEMBL1837609 | 0.87 | ALOX5 (0.48) | CYP1A2CYP2D6EPHX1HPGDKMT2A | |
| Carbamic Acid SCHEMBL7781024 | 0.87 | ALOX5 (0.45) | CYP1A2LMNACYP2D6EPHX1ALOX5 | |
| Urea SCHEMBL11805177 | 0.87 | ALOX5 (0.48) | CYP1A2CYP2D6EPHX1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6887817-B2 | Olefin polymerization catalyst and process for preparing polyolefins using said catalyst | FORMOSA PLASTICS CORPORATION, U.S.A. (US) | 2005-05-03 | — | — | US | claimed |
| US-20040039139-A1 | Olefin polymerization catalyst and process for preparing polyolefins using said catalyst | FORMOSA PLASTICS CO., U.S.A. | 2004-02-26 | — | — | US | claimed |
| US-20030069372-A1 | Olefin polymerization catalyst and process for preparing polyolefins with said catalyst | FORMOSA PLASTICS CORPORATION, U.S.A. | 2003-04-10 | — | — | US | claimed |
| US-6887817-B2 | Olefin polymerization catalyst and process for preparing polyolefins using said catalyst | FORMOSA PLASTICS CORPORATION, U.S.A. (US) | 2005-05-03 | — | — | US | disclosed |
| US-20040039139-A1 | Olefin polymerization catalyst and process for preparing polyolefins using said catalyst | FORMOSA PLASTICS CO., U.S.A. | 2004-02-26 | — | — | US | disclosed |
| US-20030069372-A1 | Olefin polymerization catalyst and process for preparing polyolefins with said catalyst | FORMOSA PLASTICS CORPORATION, U.S.A. | 2003-04-10 | — | — | US | disclosed |
| EP-0597119-B1 | CYCLOOLEFIN COPOLYMER COMPOSITION AND PRODUCTION THEREOF | MITSUI CHEMICALS INC (JP) | 2000-12-13 | — | — | EP | disclosed |
| EP-0608903-B1 | Cycloolefin polymer composition | MITSUI CHEMICALS INC (JP) | 1999-04-07 | — | — | EP | disclosed |
| US-5567777-A | CONTAINING AN ALPHA-OLEFIN; TRANSPARENCY | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-22 | — | — | US | disclosed |
| US-5567776-A | BLEND ELASTOMERIC COPOLYMERS CONTAINING ALPHA- AND CYCLO-OLEFINS; IMPACT STRENGTH, TRANSPARENCY, FIBER OPTICS | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-22 | — | — | US | disclosed |
| US-5494969-A | IMPACT STRENGTH, TRANSPARENCY, HEAT RESISTANCE | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-27 | — | — | US | disclosed |
| US-4544648-A | COORDINATION CATALYST | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1985-10-01 | — | — | US | disclosed |
| EP-0141500-A1 | Catalyst component for polymerization of olefins | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1985-05-15 | — | — | EP | disclosed |
| EP-0140536-A1 | Catalyst component for polymerization of olefins | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1985-05-08 | — | — | EP | disclosed |
| EP-0136112-A2 | Catalyst component for polymerization of olefins | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1985-04-03 | — | — | EP | disclosed |
| EP-0136113-A2 | Catalyst component for polymerization of olefins | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1985-04-03 | — | — | EP | disclosed |
| EP-0136163-A2 | Process for polymerization of olefins | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1985-04-03 | — | — | EP | disclosed |
| EP-0127487-A1 | Catalyst component for polymerization of olefins | TOA NENRYO KOGYO KABUSHIKI KAISHA (JP) | 1984-12-05 | — | — | EP | disclosed |
| EP-0126934-A2 | Process for the preparation of 1,1-disubstituted thioureas | BASF Aktiengesellschaft (DE) | 1984-12-05 | — | — | EP | disclosed |
| EP-0115691-A1 | Catalyst component for polymerization of olefins | Tonen Corporation (JP) | 1984-08-15 | — | — | EP | disclosed |