Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21994952 | 0.91 | ADORA1 (0.38) | PPARGPPARAOPRK1OPRM1GAA | |
| SCHEMBL21994950 | 0.91 | ADORA1 (0.38) | PPARGPPARAOPRK1OPRM1GAA | |
| SCHEMBL21994341 | 0.81 | MAOB (0.41) | PPARGPPARAGAAKMT2AADORA1 | |
| SCHEMBL21994342 | 0.81 | MAOB (0.41) | PPARGPPARAGAAKMT2AADORA1 | |
| SCHEMBL22035319 | 0.80 | GAA (0.40) | PPARGPPARAOPRK1GAAADORA1 | |
| SCHEMBL21994442 | 0.78 | CA2 (0.40) | OPRK1OPRM1KMT2AADORA1 | |
| SCHEMBL21994445 | 0.78 | CA2 (0.40) | OPRK1OPRM1KMT2AADORA1 | |
| SCHEMBL28961615 | 0.76 | ADAMTS5 (0.41) | KMT2AALDH1A1LMNA | |
| SCHEMBL28961616 | 0.76 | ADAMTS5 (0.41) | KMT2AALDH1A1LMNA | |
| SCHEMBL22035315 | 0.75 | ADORA1 (0.43) | PPARGPPARAGAAADORA1NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113166101-A | Cyclic pentameric compounds as proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors for the treatment of metabolic disorders | 诺华股份有限公司 | 2021-07-23 | — | — | CN | disclosed |