Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 5/20 | 0.35 |
| ▸ | F2 | P00734 | 3/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | NSD2 | O96028 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | THRB | P10828 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27225358 | 0.90 | RAPGEF4 (0.36) | RAPGEF4F2PRSS1PRSS2PRSS3 | |
| SCHEMBL31746006 | 0.83 | F2 (0.33) | RAPGEF4F2PRSS1PRSS2PRSS3 | |
| SCHEMBL20874147 | 0.80 | RAPGEF4 (0.40) | RAPGEF4F2PRSS1PRSS2PRSS3 | |
| SCHEMBL616980 | 0.80 | RAPGEF4 (0.38) | RAPGEF4F2PRSS1PRSS2PRSS3 | |
| SCHEMBL30002890 | 0.80 | RAPGEF4 (0.38) | RAPGEF4F2PRSS1PRSS2PRSS3 | |
| SCHEMBL31309368 | 0.80 | CYP2C9 (0.36) | RAPGEF4F2PRSS1PRSS2PRSS3 | |
| SCHEMBL16599611 | 0.78 | RAPGEF4 (0.36) | RAPGEF4F2PRSS1PRSS2PRSS3 | |
| SCHEMBL16913904 | 0.78 | RAPGEF4 (0.36) | RAPGEF4F2PRSS1PRSS2PRSS3 | |
| SCHEMBL30888383 | 0.78 | RAPGEF4 (0.36) | RAPGEF4F2PRSS1PRSS2PRSS3 | |
| SCHEMBL16897621 | 0.78 | KMT2A (0.36) | CA1CA2MAPK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641895-B | Indole compounds substituted with [1, 2, 4] triazolo [1, 5-a ] pyridyl | 百时美施贵宝公司 | 2021-09-03 | — | — | CN | disclosed |