SCHEMBL28628804

SCHEMBL28628804

NCCCC(Cl)c1cccnc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.47
HRH1 P35367 3/20 0.45
HTR2A P28223 1/20 0.44
SLC6A2 P23975 2/20 0.43
SLC6A4 P31645 2/20 0.43
SLC6A3 Q01959 2/20 0.43
CFTR P13569 1/20 0.43
GOPC Q9HD26 1/20 0.43
CYP19A1 P11511 1/20 0.42
CHRNA7 P36544 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.41
TBXAS1 P24557 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
ITGB3 P05106 2/20 0.39
ITGAV P06756 2/20 0.39
ITGA2B P08514 2/20 0.39
KCNA5 P22460 3/20 0.39
KCNN4 O15554 2/20 0.39
LMNA P02545 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28628803 1.00 CYP2A6 (0.47) CYP2A6HRH1HTR2ASLC6A2SLC6A4
SCHEMBL24895918 1.00 CYP2A6 (0.47) CYP2A6HRH1HTR2ASLC6A2SLC6A4
SCHEMBL30195834 1.00 CYP2A6 (0.47) CYP2A6HRH1HTR2ASLC6A2SLC6A4
SCHEMBL27215798 0.84 CFTR (0.44) SLC6A2SLC6A4SLC6A3CFTRGOPC
SCHEMBL27215799 0.84 CFTR (0.44) SLC6A2SLC6A4SLC6A3CFTRGOPC
SCHEMBL25005918 0.84 CFTR (0.44) SLC6A2SLC6A4SLC6A3CFTRGOPC
SCHEMBL30273386 0.84 CFTR (0.44) SLC6A2SLC6A4SLC6A3CFTRGOPC
SCHEMBL27530068 0.83 L3MBTL1 (0.46) SLC6A2SLC6A4SLC6A3CFTRGOPC
SCHEMBL28831206 0.82 CFTR (0.48) CYP2A6SLC6A2SLC6A4SLC6A3CFTR
Hydrochloric Acid SCHEMBL9722602 0.81 TBXAS1 (0.42) SLC6A2SLC6A4SLC6A3CFTRGOPC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113387925-B Preparation method for synthesizing S-nicotine from glutarate 深圳市真味生物科技有限公司 2023-03-28 CN claimed
CN-113387925-A Preparation method for synthesizing S-nicotine from glutarate 深圳市真味生物科技有限公司 2021-09-14 CN claimed
CN-113387925-B Preparation method for synthesizing S-nicotine from glutarate 深圳市真味生物科技有限公司 2023-03-28 CN disclosed
CN-113475739-A Preparation method of S-nicotine 深圳市真味生物科技有限公司 2021-10-08 CN disclosed
CN-113387925-A Preparation method for synthesizing S-nicotine from glutarate 深圳市真味生物科技有限公司 2021-09-14 CN disclosed