⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28526214 | 0.89 | MAOA (0.35) | — | |
| SCHEMBL22221540 | 0.80 | — | — | |
| SCHEMBL30849496 | 0.78 | MAOA (0.38) | — | |
| SCHEMBL11922751 | 0.77 | — | — | |
| SCHEMBL4343330 | 0.77 | — | — | |
| SCHEMBL3259179 | 0.76 | — | — | |
| SCHEMBL94152 | 0.76 | — | — | |
| SCHEMBL2354293 | 0.74 | TET2 (0.33) | — | |
| SCHEMBL5883451 | 0.74 | TET2 (0.33) | — | |
| SCHEMBL31083868 | 0.74 | LMNA (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119118872-A | Tetrahydronaphthalene and tetrahydroquinoline compounds as HIF-2 alpha inhibitors | 艾库斯生物科学有限公司 | 2024-12-13 | — | — | CN | disclosed |
| CN-115298165-B | Tetrahydronaphthalene and tetrahydroquinoline compounds as HIF-2 alpha inhibitors | 艾库斯生物科学有限公司 | 2024-09-17 | — | — | CN | disclosed |
| CN-115298165-A | Tetralin and tetrahydroquinoline compounds as HIF-2 alpha inhibitors | 艾库斯生物科学有限公司 | 2022-11-04 | — | — | CN | disclosed |
| CN-114760994-A | Inhibitors of HIF-2 alpha | 艾库斯生物科学有限公司 | 2022-07-15 | — | — | CN | disclosed |
| CN-113382998-A | Inhibitors of ARG1 and/or ARG2 | 艾库斯生物科学有限公司 | 2021-09-10 | — | — | CN | disclosed |