SCHEMBL28629142

SCHEMBL28629142

CC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)Oc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 4/20 0.51
CTSS P25774 3/20 0.51
CTSB P07858 2/20 0.51
CTSK P43235 2/20 0.51
CTSD P07339 1/20 0.51
PSEN1 P49768 4/20 0.50
PSEN2 P49810 4/20 0.50
APH1B Q8WW43 4/20 0.50
NCSTN Q92542 4/20 0.50
APH1A Q96BI3 4/20 0.50
PSENEN Q9NZ42 4/20 0.50
ALDH1A1 P00352 1/20 0.50
GAA P10253 1/20 0.50
MAPT P10636 1/20 0.50
ITGA4 P13612 1/20 0.49
ITGB7 P26010 1/20 0.49
REN P00797 3/20 0.48
KLK5 Q9Y337 1/20 0.47
PPARG P37231 1/20 0.47
PPARA Q07869 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26226869 1.00 CTSL (0.51) CTSLCTSSCTSBCTSKCTSD
SCHEMBL883397 0.89 ITGA4 (0.55) CTSLCTSSCTSBCTSKALDH1A1
SCHEMBL6988240 0.89 ITGA4 (0.55) CTSLCTSSCTSBCTSKALDH1A1
SCHEMBL495975 0.89 ITGA4 (0.55) CTSLCTSSCTSBCTSKALDH1A1
SCHEMBL6889410 0.85 PPARG (0.55) CTSLCTSSCTSBCTSKALDH1A1
SCHEMBL19668455 0.84 MAPT (0.64) ALDH1A1GAAMAPTPPARGPPARA
SCHEMBL7341887 0.84 MAPT (0.64) ALDH1A1GAAMAPTPPARGPPARA
SCHEMBL9069779 0.83 PPARG (0.47) CTSLCTSSCTSBCTSKALDH1A1
SCHEMBL1221478 0.83 ITGA4 (0.60) CTSLCTSSCTSBCTSKMAPT
SCHEMBL3821796 0.83 PPARA (0.60) CTSLCTSSCTSBCTSKITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113195641-A Sulfoxonium ylide derivatives as probes for cysteine proteases 武田药品工业株式会社 2021-07-30 CN disclosed