Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165175 | 0.88 | KDM4E (0.66) | KDM4EPOLBHTTGAAL3MBTL1 | |
| SCHEMBL1953578 | 0.87 | POLB (0.61) | KDM4EPOLBHTTL3MBTL1NPC1 | |
| SCHEMBL15600792 | 0.86 | PKM (0.54) | KDM4EPOLBHTTL3MBTL1NPC1 | |
| SCHEMBL21816696 | 0.86 | HTT (0.49) | KDM4EPOLBHTTL3MBTL1NPC1 | |
| SCHEMBL2899450 | 0.86 | POLB (0.52) | KDM4EPOLBHTTGAAL3MBTL1 | |
| SCHEMBL28641985 | 0.85 | KDM4E (0.43) | KDM4EPOLBHTTGAAL3MBTL1 | |
| SCHEMBL24525512 | 0.83 | PDGFRB (0.51) | KDM4EGAACYP3A4TDP1LMNA | |
| SCHEMBL5256629 | 0.83 | POLB (0.50) | KDM4EPOLBHTTL3MBTL1NPC1 | |
| SCHEMBL18700346 | 0.83 | PDGFRB (0.51) | KDM4EPOLBHTTL3MBTL1NPC1 | |
| SCHEMBL29734700 | 0.83 | POLB (0.50) | KDM4EPOLBHTTL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107793413-B | Pyrimidine heterocyclic compound and preparation method and application thereof | 上海科州药物研发有限公司 | 2021-09-28 | — | — | CN | disclosed |