Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28630778 | 0.85 | KDM4E (0.57) | KDM4ETDP1SIRT6POLBHTT | |
| SCHEMBL24616176 | 0.84 | POLB (0.41) | TDP1SIRT6PDGFRBFGFR1PDGFRA | |
| SCHEMBL28203549 | 0.84 | ALDH1A1 (0.37) | TDP1POLBHTTCYP3A4MEN1 | |
| SCHEMBL24525104 | 0.81 | CFTR (0.51) | KDM4ECFTRTDP1SIRT6PDGFRB | |
| SCHEMBL26814624 | 0.79 | KDM4E (0.49) | KDM4ECFTRPOLBGAA | |
| SCHEMBL1679937 | 0.78 | TDP1 (0.50) | TDP1SIRT6PDGFRBFGFR1PDGFRA | |
| SCHEMBL24525512 | 0.77 | PDGFRB (0.51) | KDM4ECFTRTDP1SIRT6PDGFRB | |
| SCHEMBL8608691 | 0.77 | SLC9A1 (0.40) | TDP1SIRT6PDGFRBFGFR1PDGFRA | |
| SCHEMBL8610762 | 0.77 | SLC9A1 (0.47) | KDM4ETDP1SIRT6PDGFRBFGFR1 | |
| SCHEMBL11397555 | 0.77 | KDM4E (0.53) | KDM4ECFTRTDP1SIRT6PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107793413-B | Pyrimidine heterocyclic compound and preparation method and application thereof | 上海科州药物研发有限公司 | 2021-09-28 | — | — | CN | disclosed |