Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL29207396 | 0.91 | KMT2A (0.58) | KMT2AMEN1KDM4EGAACYP2C9 | |
| Morpholine SCHEMBL219044 | 0.91 | KMT2A (0.58) | KMT2AMEN1KDM4EGAACYP2C9 | |
| Acetic Acid SCHEMBL10708681 | 0.88 | MEN1 (0.63) | KMT2AMEN1KDM4EGAACYP2C9 | |
| Morpholine SCHEMBL29076892 | 0.88 | KMT2A (0.55) | KMT2AMEN1KDM4EGAACYP2C9 | |
| Acetic Acid SCHEMBL10707147 | 0.88 | MEN1 (0.63) | KMT2AMEN1KDM4EGAACYP2C9 | |
| Acetic Acid SCHEMBL28048691 | 0.88 | KDM4E (0.63) | KMT2AMEN1KDM4EGAACYP2C9 | |
| Morpholine SCHEMBL2808233 | 0.88 | MEN1 (0.61) | KMT2AMEN1KDM4EGAACYP2C9 | |
| Morpholine SCHEMBL2808231 | 0.88 | MEN1 (0.61) | KMT2AMEN1KDM4EGAACYP2C9 | |
| Morpholine SCHEMBL28072685 | 0.88 | MEN1 (0.61) | KMT2AMEN1KDM4EGAACYP2C9 | |
| Morpholine SCHEMBL15572290 | 0.86 | MEN1 (0.52) | KMT2AMEN1KDM4EGAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109260043-B | Deodorizing preparation for dyeing/perming agent and deodorizing hair care liquid | 郭金龙 | 2021-10-08 | — | — | CN | claimed |
| CN-109260043-B | Deodorizing preparation for dyeing/perming agent and deodorizing hair care liquid | 郭金龙 | 2021-10-08 | — | — | CN | disclosed |