Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK3 | Q9NZJ5 | 10/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.48 |
| ▸ | ABL1 | P00519 | 8/20 | 0.48 |
| ▸ | EGFR | P00533 | 8/20 | 0.48 |
| ▸ | HCK | P08631 | 8/20 | 0.48 |
| ▸ | SRC | P12931 | 8/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.48 |
| ▸ | MTOR | P42345 | 8/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.48 |
| ▸ | PRKDC | P78527 | 8/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | KIF5B | P33176 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30442066 | 0.85 | FLT3 (0.51) | EIF2AK3RETFLT3 | |
| SCHEMBL20351744 | 0.83 | SRC (0.57) | EIF2AK3PIK3CDABL1EGFRHCK | |
| SCHEMBL22418477 | 0.82 | TEK (0.52) | EIF2AK3ABL1EGFRSRCKDR | |
| SCHEMBL24458348 | 0.81 | RET (0.56) | EIF2AK3PIK3CDABL1EGFRHCK | |
| SCHEMBL20351737 | 0.77 | ABL1 (0.66) | EIF2AK3PIK3CDABL1EGFRHCK | |
| SCHEMBL22676745 | 0.75 | SRC (0.67) | EIF2AK3PIK3CDABL1EGFRHCK | |
| SCHEMBL22677981 | 0.75 | SRC (0.55) | EIF2AK3ABL1EGFRSRCKDR | |
| SCHEMBL29407781 | 0.75 | SRC (0.55) | EIF2AK3ABL1EGFRSRCKDR | |
| SCHEMBL7835001 | 0.75 | SRC (0.73) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL31264664 | 0.74 | EIF2AK3 (0.50) | EIF2AK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036014-B | Compound with AXL inhibitory activity and preparation and application thereof | 中国科学院上海药物研究所 | 2021-09-07 | — | — | CN | disclosed |