Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 9/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MMP2 | P08253 | 3/20 | 0.36 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26638292 | 1.00 | JAK1 (0.39) | JAK1L3MBTL1MMP2ANPEPALDH1A1 | |
| SCHEMBL26638298 | 0.85 | L3MBTL1 (0.38) | JAK1L3MBTL1POLBALDH3A1HTT | |
| SCHEMBL29172445 | 0.85 | L3MBTL1 (0.36) | JAK1L3MBTL1ALDH1A1KMT2APOLB | |
| SCHEMBL26638303 | 0.84 | L3MBTL1 (0.38) | JAK1L3MBTL1POLBALDH3A1HTT | |
| SCHEMBL28621769 | 0.84 | JAK1 (0.52) | JAK1L3MBTL1KMT2APOLBJAK2 | |
| SCHEMBL30622213 | 0.84 | JAK1 (0.52) | JAK1L3MBTL1KMT2APOLBJAK2 | |
| SCHEMBL28634235 | 0.84 | JAK1 (0.52) | JAK1L3MBTL1KMT2APOLBJAK2 | |
| SCHEMBL30622180 | 0.84 | JAK1 (0.52) | JAK1L3MBTL1KMT2APOLBJAK2 | |
| SCHEMBL28626461 | 0.84 | L3MBTL1 (0.38) | JAK1L3MBTL1ALDH1A1POLBALDH3A1 | |
| SCHEMBL26638305 | 0.83 | L3MBTL1 (0.37) | JAK1L3MBTL1POLBALDH3A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118406052-A | Tricyclic JANUS kinase 1 inhibitors and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-30 | — | — | CN | disclosed |
| CN-113396150-B | Tricyclic JANUS kinase 1 inhibitors and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-03-12 | — | — | CN | disclosed |