Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 6/20 | 0.56 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.56 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28225240 | 0.79 | MKNK1 (0.60) | CYP11B1CYP11B2CYP19A1CYP17A1MKNK1 | |
| SCHEMBL28018862 | 0.77 | CYP11B1 (0.56) | CYP11B1CYP11B2CYP19A1CYP17A1MKNK1 | |
| SCHEMBL28118939 | 0.77 | CYP11B1 (0.61) | CYP11B1CYP11B2CYP19A1CYP17A1MKNK1 | |
| SCHEMBL23326169 | 0.75 | MKNK1 (0.56) | CYP11B1CYP11B2CYP19A1CYP17A1MKNK1 | |
| SCHEMBL29775379 | 0.75 | MKNK1 (0.56) | CYP11B1CYP11B2CYP19A1CYP17A1MKNK1 | |
| SCHEMBL4506402 | 0.75 | CYP11B1 (0.60) | CYP11B1CYP11B2CYP19A1CYP17A1MKNK1 | |
| SCHEMBL14680957 | 0.75 | MKNK1 (0.63) | CYP11B1CYP11B2CYP19A1CYP17A1MKNK1 | |
| SCHEMBL12381484 | 0.74 | CYP11B1 (0.74) | CYP11B1CYP11B2CYP19A1CYP17A1MKNK1 | |
| SCHEMBL31663902 | 0.74 | MKNK1 (0.62) | CYP11B1CYP11B2CYP19A1CYP17A1MKNK1 | |
| SCHEMBL21076869 | 0.74 | MKNK1 (0.66) | CYP11B1CYP11B2CYP19A1CYP17A1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113574055-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-113412258-A | PCSK9 inhibitors and methods of use thereof | 阿斯利康(瑞典)有限公司 | 2021-09-17 | — | — | CN | disclosed |