Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 20/20 | 0.54 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286291 | 0.89 | GABRA5 (0.68) | GABRA5GABRA1 | |
| SCHEMBL286658 | 0.85 | GABRA5 (0.59) | GABRA5GABRG2GABRB3KCNH2 | |
| SCHEMBL286044 | 0.85 | GABRA5 (0.59) | GABRA5GABRG2GABRB3KCNH2 | |
| SCHEMBL286151 | 0.85 | GABRA5 (0.59) | GABRA5GABRG2GABRB3KCNH2 | |
| SCHEMBL2098576 | 0.85 | GABRA5 (0.59) | GABRA5GABRA1 | |
| SCHEMBL297776 | 0.85 | GABRA5 (0.59) | GABRA5GABRA1 | |
| SCHEMBL285690 | 0.85 | GABRA5 (0.60) | GABRA5GABRG2GABRB3KCNH2GABRA1 | |
| SCHEMBL2628064 | 0.85 | GABRA5 (0.60) | GABRA5GABRG2GABRB3KCNH2GABRA1 | |
| SCHEMBL296065 | 0.85 | GABRA5 (0.59) | GABRA5GABRA1 | |
| SCHEMBL286327 | 0.83 | GABRA5 (0.71) | GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |