Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2674305 | 1.00 | SLC6A4 (0.46) | SLC6A4MEN1LMNAKMT2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL2749385 | 0.98 | SLC6A4 (0.44) | SLC6A4MEN1LMNAKMT2ACYP1A2 | |
| SCHEMBL20184239 | 0.82 | ADRA2A (0.39) | MEN1LMNAKMT2ACYP1A2CYP2E1 | |
| SCHEMBL2760888 | 0.82 | ADRA2A (0.39) | MEN1LMNAKMT2ACYP1A2CYP2E1 | |
| SCHEMBL14480428 | 0.82 | ADRA2A (0.39) | MEN1LMNAKMT2ACYP1A2CYP2E1 | |
| Hydrochloric Acid SCHEMBL1440347 | 0.81 | ADRA2A (0.41) | MEN1LMNAKMT2ACYP1A2CYP2E1 | |
| Hydrochloric Acid SCHEMBL1440350 | 0.81 | ADRA2A (0.41) | MEN1LMNAKMT2ACYP1A2CYP2E1 | |
| Hydrochloric Acid SCHEMBL1440719 | 0.81 | ADRA2A (0.41) | MEN1LMNAKMT2ACYP1A2CYP2E1 | |
| SCHEMBL998729 | 0.79 | P2RX3 (0.37) | MEN1LMNAKMT2ACYP1A2CYP2E1 | |
| SCHEMBL998728 | 0.79 | P2RX3 (0.37) | MEN1LMNAKMT2ACYP1A2CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139334-A1 | 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| EP-2136639-A1 | PYRID-2-YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008130481-A1 | 2-CYANOPHENYL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| WO-2008123963-A1 | PYRID-2-YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |