Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | JUN | P05412 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | WEE1 | P30291 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28637026 | 0.90 | BRAF (0.48) | BRAFFGFR4PDGFRBPDGFRAEGFR | |
| SCHEMBL28637030 | 0.84 | BRAF (0.43) | BRAFFGFR4CCNT1CDK9EGFR | |
| SCHEMBL28645228 | 0.82 | BRAF (0.44) | BRAFFGFR4MAPK10CDK2CCNT1 | |
| SCHEMBL28632697 | 0.81 | NTRK1 (0.45) | BRAFFGFR4CDK2CCNT1CDK9 | |
| SCHEMBL28650920 | 0.81 | FGFR4 (0.58) | BRAFFGFR4EGFRWEE1 | |
| SCHEMBL2859316 | 0.79 | PDGFRB (0.51) | PDGFRBPDGFRAJUNMAPK10FGFR1 | |
| SCHEMBL28632311 | 0.78 | FGFR4 (0.42) | BRAFFGFR4CDK2CCNT1CCNA2 | |
| SCHEMBL28637028 | 0.78 | BRAF (0.45) | BRAFFGFR4CDK2CCNT1CCNA2 | |
| SCHEMBL1736410 | 0.77 | RIPK2 (0.51) | GALR2 | |
| SCHEMBL28645231 | 0.77 | FGFR4 (0.42) | BRAFFGFR4CCNT1CDK9EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354622-B | P-phenylenediamine LSD1 inhibitor and preparation method thereof | 沈阳药科大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-113354622-A | P-phenylenediamine LSD1 inhibitor and preparation method thereof | 沈阳药科大学 | 2021-09-07 | — | — | CN | disclosed |