Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 2/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28635967 | 0.90 | BRAF (0.46) | BRAFFGFR4PDGFRBPDGFRAEGFR | |
| SCHEMBL28650920 | 0.83 | FGFR4 (0.58) | BRAFFGFR4EGFR | |
| SCHEMBL28632311 | 0.81 | FGFR4 (0.42) | BRAFFGFR4EGFRFYNCDK4 | |
| SCHEMBL28637028 | 0.81 | BRAF (0.45) | BRAFFGFR4EGFRCSNK2A1CDK4 | |
| SCHEMBL28645228 | 0.80 | BRAF (0.44) | BRAFFGFR4EGFRCSNK2A1CDK4 | |
| SCHEMBL28645231 | 0.80 | FGFR4 (0.42) | BRAFFGFR4EGFRCSNK2A1CDK4 | |
| SCHEMBL28637030 | 0.80 | BRAF (0.43) | BRAFFGFR4EGFRAXLCSNK2A1 | |
| SCHEMBL28652402 | 0.79 | CHEK1 (0.49) | BRAFFGFR4EGFRCSNK2A1CDK4 | |
| SCHEMBL28632697 | 0.79 | NTRK1 (0.45) | BRAFFGFR4EGFRCDK4CCND1 | |
| SCHEMBL28924728 | 0.78 | WEE1 (0.44) | BRAFFGFR4EGFRAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354622-B | P-phenylenediamine LSD1 inhibitor and preparation method thereof | 沈阳药科大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-113354622-A | P-phenylenediamine LSD1 inhibitor and preparation method thereof | 沈阳药科大学 | 2021-09-07 | — | — | CN | disclosed |