Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TXN | P10599 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28637028 | 0.88 | BRAF (0.45) | BRAFCSNK2A1ALDH1A1MAPK1MEN1 | |
| SCHEMBL28652402 | 0.87 | CHEK1 (0.49) | BRAFCSNK2A1ALDH1A1EGFRFGFR4 | |
| SCHEMBL28632697 | 0.86 | NTRK1 (0.45) | BRAFEGFRFGFR4CCNT1CDK9 | |
| SCHEMBL28637030 | 0.84 | BRAF (0.43) | BRAFCSNK2A1EGFRFGFR4CCNT1 | |
| SCHEMBL28645231 | 0.82 | FGFR4 (0.42) | BRAFCSNK2A1EGFRFGFR4HDAC3 | |
| SCHEMBL28635967 | 0.82 | BRAF (0.46) | BRAFEGFRFGFR4MAPK10CCNT1 | |
| SCHEMBL28641910 | 0.81 | FGFR4 (0.42) | BRAFCYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL28643660 | 0.80 | FGFR4 (0.39) | BRAFCSNK2A1USP2ALDH1A1CYP1A2 | |
| SCHEMBL28643653 | 0.80 | IKBKB (0.44) | BRAFCSNK2A1EGFRFGFR4CCNT1 | |
| SCHEMBL28637026 | 0.80 | BRAF (0.48) | BRAFCSNK2A1EGFRFGFR4CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354622-B | P-phenylenediamine LSD1 inhibitor and preparation method thereof | 沈阳药科大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-113354622-A | P-phenylenediamine LSD1 inhibitor and preparation method thereof | 沈阳药科大学 | 2021-09-07 | — | — | CN | disclosed |