Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NSD2 | O96028 | 2/20 | 0.37 |
| ▸ | NSD3 | Q9BZ95 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30335860 | 0.71 | PRMT5 (0.46) | NSD2NSD3LMNAHPGD | |
| SCHEMBL2078531 | 0.67 | JAK3 (0.37) | ALDH1A1LMNAKDM4EMAPK1GLA | |
| SCHEMBL30515984 | 0.67 | PDE8B (0.46) | MAPTALDH1A1LMNAKDM4EGLA | |
| SCHEMBL29063941 | 0.67 | PDE8B (0.46) | MAPTALDH1A1LMNAKDM4EGLA | |
| SCHEMBL2075577 | 0.64 | PKM (0.49) | ALDH1A1LMNAKDM4EMAPK1GLA | |
| SCHEMBL30914201 | 0.64 | MEN1 (0.46) | NSD2NSD3MAPTKDM4EMAPK1 | |
| SCHEMBL24128361 | 0.63 | KMT2A (0.37) | ALDH1A1LMNAKDM4EGLAGAA | |
| SCHEMBL23906401 | 0.63 | ADORA2A (0.37) | — | |
| SCHEMBL28646118 | 0.62 | ADORA2A (0.46) | NSD2MAPTALDH1A1KDM4EMAPK1 | |
| SCHEMBL19630056 | 0.61 | ENPP1 (0.40) | ALDH1A1KDM4EGAAHPGDEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527337-A | Fused ring compounds as FGFR4 inhibitors | 齐鲁制药有限公司 | 2021-10-22 | — | — | CN | disclosed |