Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 5/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21089822 | 1.00 | GLS (0.48) | GLSBRD4KDM4ACREBBPNAMPT | |
| SCHEMBL12318659 | 0.90 | GLS (0.49) | GLSBRD4KDM4ACREBBPNAMPT | |
| SCHEMBL27779357 | 0.88 | GLS (0.47) | GLSBRD4KDM4ACREBBPNAMPT | |
| SCHEMBL13715120 | 0.86 | GLS (0.46) | GLSBRD4KDM4ACREBBPNAMPT | |
| SCHEMBL14898071 | 0.85 | GLS (0.48) | GLSBRD4KDM4ACREBBPNAMPT | |
| SCHEMBL25908751 | 0.84 | GLS (0.51) | GLSBRD4KDM4ACREBBPNAMPT | |
| SCHEMBL23413688 | 0.83 | GLS (0.46) | GLSBRD4KDM4ACREBBPCTSK | |
| SCHEMBL31389110 | 0.82 | SYK (0.46) | GLSBRD4KDM4ACREBBPNAMPT | |
| SCHEMBL30771369 | 0.81 | SYK (0.46) | GLSBRD4KDM4ACREBBPNAMPT | |
| SCHEMBL7865716 | 0.81 | GLS (0.49) | GLSBRD4KDM4ACREBBPNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109689661-B | Macrocyclic inhibitors of myeloperoxidase | 百时美施贵宝公司 | 2021-10-15 | — | — | CN | disclosed |