Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628060 | 1.00 | GABRA5 (0.44) | GABRA5GABRA1 | |
| SCHEMBL286080 | 1.00 | GABRA5 (0.44) | GABRA5GABRA1 | |
| SCHEMBL286160 | 0.93 | GABRA5 (0.42) | GABRA5GABRA1 | |
| SCHEMBL286162 | 0.92 | GABRA5 (0.43) | GABRA5GABRA1 | |
| SCHEMBL286340 | 0.85 | GABRA5 (0.44) | GABRA5GABRA1 | |
| SCHEMBL7791577 | 0.85 | GABRA5 (0.47) | GABRA5GABRA1 | |
| SCHEMBL7791584 | 0.85 | GABRA5 (0.47) | GABRA5GABRA1 | |
| SCHEMBL7802104 | 0.85 | GABRA5 (0.47) | GABRA5GABRA1 | |
| SCHEMBL286161 | 0.85 | POLB (0.40) | GABRA5GABRA1 | |
| SCHEMBL286394 | 0.84 | L3MBTL1 (0.35) | GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163728-B2 | Pyrazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | claimed |
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | claimed |
| US-8163728-B2 | Pyrazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |