Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 2/20 | 0.32 |
| ▸ | PLG | P00747 | 2/20 | 0.32 |
| ▸ | PLAU | P00749 | 2/20 | 0.32 |
| ▸ | PLAT | P00750 | 2/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28642986 | 0.80 | SLC18A3 (0.36) | TSHRPOLB | |
| SCHEMBL23793815 | 0.77 | TSHR (0.34) | TSHRPLGPLAUPLATKDM4E | |
| SCHEMBL28926824 | 0.77 | CNR2 (0.34) | KDM4EALDH1A1NPC1HPGDRAB9A | |
| SCHEMBL25484300 | 0.76 | TSHR (0.33) | TSHRPOLB | |
| SCHEMBL28645681 | 0.75 | DHODH (0.34) | — | |
| SCHEMBL25494208 | 0.73 | TSHR (0.32) | TSHRPOLB | |
| SCHEMBL26034932 | 0.73 | GRIN2D (0.37) | TSHRKDM4EALDH1A1HTR1APOLB | |
| SCHEMBL25495087 | 0.73 | TSHR (0.32) | TSHRPOLB | |
| SCHEMBL22090081 | 0.72 | GRIN2D (0.40) | TSHRPLGPLAUPLATKDM4E | |
| SCHEMBL22089827 | 0.72 | ALDH1A3 (0.47) | TSHRALDH1A1POLBNPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113412113-B | Amino oxazinamides | 豪夫迈·罗氏有限公司 | 2024-07-26 | — | — | CN | disclosed |
| CN-113412113-A | Aminooxazine amides | 豪夫迈·罗氏有限公司 | 2021-09-17 | — | — | CN | disclosed |