SCHEMBL28638656

SCHEMBL28638656

CNCCCCn1c(=O)c(-c2cccc(F)c2Cl)cn(CC(=O)OC)c1=O

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GNRHR P30968 14/20 0.41
CYP3A4 P08684 9/20 0.41
EGFR P00533 1/20 0.35
PTGDR Q13258 1/20 0.34
NOD1 Q9Y239 2/20 0.33
KDM4E B2RXH2 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
PDCD1 Q15116 1/20 0.33
CD274 Q9NZQ7 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28645661 0.87 GNRHR (0.40) GNRHRCYP3A4EGFRKDM4ESMN1; SMN2
SCHEMBL28644084 0.86 GNRHR (0.39) GNRHRCYP3A4NOD1PDCD1CD274
SCHEMBL28651462 0.85 GNRHR (0.41) GNRHRCYP3A4EGFRPTGDRKDM4E
SCHEMBL28638657 0.84 GNRHR (0.41) GNRHRCYP3A4EGFRPDCD1CD274
SCHEMBL28638881 0.83 GNRHR (0.40) GNRHRCYP3A4EGFRPTGDRKDM4E
SCHEMBL30178388 0.82 GNRHR (0.39) GNRHRCYP3A4EGFRKDM4ESMN1; SMN2
SCHEMBL28660744 0.82 GNRHR (0.40) GNRHRCYP3A4
SCHEMBL28644101 0.79 GNRHR (0.40) GNRHRCYP3A4EGFRPTGDRKDM4E
SCHEMBL28645644 0.79 GNRHR (0.37) GNRHRCYP3A4PDCD1CD274
SCHEMBL19873682 0.77 GNRHR (0.44) GNRHRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107428744-B Novel heterocyclic compounds and their use in medicine and cosmetics 盖尔德马研究及发展公司 2021-09-24 CN disclosed