SCHEMBL28660744

SCHEMBL28660744

COC(=O)Cn1cc(-c2cccc(F)c2Cl)c(=O)n(CCNC(=O)OC(C)(C)C)c1=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GNRHR P30968 8/20 0.40
CYP3A4 P08684 6/20 0.40
DRD2 P14416 3/20 0.36
IDO1 P14902 1/20 0.35
PDPK1 O15530 1/20 0.35
CCNB2 O95067 1/20 0.35
PRKCB P05771 1/20 0.35
CDK1 P06493 1/20 0.35
LYN P07948 1/20 0.35
CCNB1 P14635 1/20 0.35
CCNA2 P20248 1/20 0.35
CDK2 P24941 1/20 0.35
GSK3B P49841 1/20 0.35
RPS6KA3 P51812 1/20 0.35
CCNA1 P78396 1/20 0.35
CCNB3 Q8WWL7 1/20 0.35
MALT1 Q9UDY8 1/20 0.35
SCN9A Q15858 1/20 0.35
TPSAB1 Q15661 1/20 0.35
TPSD1 Q9BZJ3 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17870723 0.92 GNRHR (0.41) GNRHRCYP3A4DRD2IDO1MALT1
SCHEMBL30178348 0.92 GNRHR (0.41) GNRHRCYP3A4DRD2IDO1MALT1
SCHEMBL28639211 0.91 DRD2 (0.43) GNRHRCYP3A4DRD2PDPK1CCNB2
SCHEMBL19873836 0.88 DRD2 (0.36) GNRHRCYP3A4DRD2IDO1PDPK1
SCHEMBL30178472 0.88 DRD2 (0.36) GNRHRCYP3A4DRD2IDO1PDPK1
SCHEMBL28645644 0.84 GNRHR (0.37) GNRHRCYP3A4
SCHEMBL17870746 0.83 MALT1 (0.38) GNRHRCYP3A4DRD2IDO1MALT1
SCHEMBL30178350 0.83 DRD2 (0.44) GNRHRCYP3A4DRD2MALT1CAMK2D
SCHEMBL17870795 0.83 DRD2 (0.44) GNRHRCYP3A4DRD2MALT1CAMK2D
SCHEMBL28644183 0.83 GNRHR (0.35) GNRHRCYP3A4IDO1PDPK1CCNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107428744-B Novel heterocyclic compounds and their use in medicine and cosmetics 盖尔德马研究及发展公司 2021-09-24 CN disclosed