SCHEMBL28639211

SCHEMBL28639211

COC(=O)Cn1cc(-c2cccc(Cl)c2Cl)c(=O)n(CCNC(=O)OC(C)(C)C)c1=O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 4/20 0.43
CYP3A4 P08684 1/20 0.37
GNRHR P30968 1/20 0.37
LMNA P02545 3/20 0.37
HPGD P15428 2/20 0.37
GAA P10253 1/20 0.37
MALT1 Q9UDY8 1/20 0.36
PDPK1 O15530 1/20 0.36
CCNB2 O95067 1/20 0.36
PRKCB P05771 1/20 0.36
CDK1 P06493 1/20 0.36
LYN P07948 1/20 0.36
CCNB1 P14635 1/20 0.36
CCNA2 P20248 1/20 0.36
CDK2 P24941 1/20 0.36
GSK3B P49841 1/20 0.36
RPS6KA3 P51812 1/20 0.36
CCNA1 P78396 1/20 0.36
CCNB3 Q8WWL7 1/20 0.36
ABL1 P00519 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30178350 0.92 DRD2 (0.44) DRD2CYP3A4GNRHRLMNAHPGD
SCHEMBL17870795 0.92 DRD2 (0.44) DRD2CYP3A4GNRHRLMNAHPGD
SCHEMBL28660744 0.91 GNRHR (0.40) DRD2CYP3A4GNRHRMALT1PDPK1
SCHEMBL19873832 0.87 DRD2 (0.43) DRD2CYP3A4GNRHRLMNAHPGD
SCHEMBL30178348 0.83 GNRHR (0.41) DRD2CYP3A4GNRHRMALT1
SCHEMBL17870723 0.83 GNRHR (0.41) DRD2CYP3A4GNRHRMALT1
SCHEMBL28641611 0.79 GNRHR (0.43) CYP3A4GNRHRKDM4ESMN1; SMN2
SCHEMBL19873836 0.79 DRD2 (0.36) DRD2CYP3A4GNRHRMALT1PDPK1
SCHEMBL30178472 0.79 DRD2 (0.36) DRD2CYP3A4GNRHRMALT1PDPK1
SCHEMBL28653804 0.78 DRD2 (0.38) DRD2MALT1ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107428744-B Novel heterocyclic compounds and their use in medicine and cosmetics 盖尔德马研究及发展公司 2021-09-24 CN disclosed