Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 9/20 | 0.49 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PFKFB4 | Q16877 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL793726 | 0.85 | PFKFB3 (0.67) | PFKFB3LNPEPGAAPFKFB4CYP19A1 | |
| SCHEMBL794304 | 0.84 | PFKFB3 (0.63) | PFKFB3LNPEPPFKFB4MMP2MMP9 | |
| SCHEMBL793409 | 0.84 | PFKFB3 (0.55) | PFKFB3LNPEPPTGES2MEN1KMT2A | |
| SCHEMBL27943370 | 0.82 | MMP2 (0.59) | PFKFB3GAAPFKFB4MMP2MMP9 | |
| SCHEMBL794544 | 0.81 | PFKFB3 (0.59) | PFKFB3LNPEPPFKFB4MMP2MMP9 | |
| SCHEMBL793555 | 0.81 | PFKFB3 (0.66) | PFKFB3LNPEPPFKFB4MEN1KMT2A | |
| SCHEMBL793332 | 0.80 | PFKFB3 (0.55) | PFKFB3LNPEPGAAPFKFB4CYP19A1 | |
| SCHEMBL793433 | 0.79 | PFKFB4 (0.67) | PFKFB3PFKFB4CYP19A1PKM | |
| SCHEMBL794311 | 0.78 | PFKFB3 (0.65) | PFKFB3LNPEPPFKFB4MEN1KMT2A | |
| SCHEMBL794222 | 0.78 | PFKFB3 (0.56) | PFKFB3LNPEPGAAPFKFB4CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | disclosed |