Sugi Predict

Sugi Predict / Compounds / SCHEMBL2864291

SCHEMBL2864291

SCHEMBL2864291

CC(=O)Oc1ccc(Cl)c(-n2nc3c(c2N)c(=O)[nH]c2ccccc23)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE2A O00408 5/20 0.42
▸ ADORA3 P0DMS8 4/20 0.41
▸ ADORA1 P30542 2/20 0.40
▸ ADORA2A P29274 1/20 0.40
▸ ELANE P08246 1/20 0.37
▸ NPSR1 Q6W5P4 1/20 0.35
▸ CHEK1 O14757 1/20 0.35
▸ TUBB4A P04350 1/20 0.35
▸ TUBB P07437 1/20 0.35
▸ TUBA3C P0DPH7 1/20 0.35
▸ TUBA1B P68363 1/20 0.35
▸ TUBA4A P68366 1/20 0.35
▸ TUBB4B P68371 1/20 0.35
▸ TUBB3 Q13509 1/20 0.35
▸ TUBB2A Q13885 1/20 0.35
▸ TUBB8 Q3ZCM7 1/20 0.35
▸ TUBA3E Q6PEY2 1/20 0.35
▸ TUBA1A Q71U36 1/20 0.35
▸ TUBA1C Q9BQE3 1/20 0.35
▸ TUBB6 Q9BUF5 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2870546 0.88 PDE2A (0.47) PDE2AADORA3ADORA1NPSR1KDM4E
SCHEMBL2860183 0.83 FGFR1 (0.46) PDE2AADORA3CHEK1KDM4EGAA
SCHEMBL2871518 0.83 PDE2A (0.47) PDE2AADORA3CHEK1KDM4E
SCHEMBL2861307 0.79 ADORA3 (0.43) ADORA3NPSR1CHEK1KDM4EGAA
SCHEMBL2859234 0.79 ALOX12 (0.52) ADORA3ADORA1NPSR1CHEK1KDM4E
SCHEMBL2866719 0.78 PDE2A (0.43) PDE2ANPSR1CHEK1KDM4EGAA
SCHEMBL2864647 0.78 PDE2A (0.44) PDE2AADORA3NPSR1CHEK1KDM4E
SCHEMBL2868559 0.77 ADORA3 (0.47) ADORA3ADORA1NPSR1CHEK1KDM4E
SCHEMBL2865205 0.77 ADORA3 (0.47) ADORA3ADORA1NPSR1KDM4E
SCHEMBL2858990 0.77 PDE2A (0.45) PDE2AADORA3ADORA1NPSR1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7842701-B2 Pyrazoloquinolone derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-11-30 — — US disclosed
US-7842701-B2 Pyrazoloquinolone derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-11-30 — — US disclosed
US-7842701-B2 Pyrazoloquinolone derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-11-30 — — US disclosed
US-20070281963-A1 Pyrazoloquinolone Derivative And Use Thereof TAKEDA PHARMACEUTICAL COMPANY (JP) 2007-12-06 — — US disclosed
US-20070281963-A1 Pyrazoloquinolone Derivative And Use Thereof TAKEDA PHARMACEUTICAL COMPANY (JP) 2007-12-06 — — US disclosed
US-20070281963-A1 Pyrazoloquinolone Derivative And Use Thereof TAKEDA PHARMACEUTICAL COMPANY (JP) 2007-12-06 — — US disclosed
EP-1719771-A1 PYRAZOLOQUINOLONE DERIVATIVE AND USE THEREOF Takeda Pharmaceutical Company Limited (JP) 2006-11-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070281963-A1 Pyrazoloquinolone Derivative And Use Thereof MAP3K20, MAP4K5, MAP4K3 PDE2A 2228/4885ADORA3 1829/4885ADORA1 2477/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.