Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 5/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635767 | 0.86 | SMN1; SMN2 (0.45) | GPR119MEN1KMT2ANPC1LMNA | |
| SCHEMBL28647264 | 0.85 | NR1H2 (0.39) | NR1H2NR1H3GPR119NPC1LMNA | |
| SCHEMBL19618968 | 0.78 | MRGPRX4 (0.47) | MEN1KMT2ALMNAHTTSMN1; SMN2 | |
| SCHEMBL24378074 | 0.77 | MAPT (0.39) | MEN1KMT2ALMNASMN1; SMN2HPGD | |
| SCHEMBL19635143 | 0.77 | MAPK13 (0.43) | MEN1KMT2ALMNATP53MAPT | |
| SCHEMBL19615237 | 0.77 | KMT2A (0.46) | MEN1KMT2ALMNAHTTTP53 | |
| Hydrochloric Acid SCHEMBL19615637 | 0.76 | MCL1 (0.42) | MEN1KMT2ALMNAMAPT | |
| SCHEMBL19615199 | 0.74 | MCL1 (0.41) | MEN1KMT2ALMNASMN1; SMN2TP53 | |
| SCHEMBL19635285 | 0.74 | MAPT (0.43) | MEN1KMT2ANPC1SMN1; SMN2HPGD | |
| SCHEMBL29291172 | 0.72 | NR1H2 (0.53) | NR1H2NR1H3GPR119LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109715632-B | Macrocyclic indole derivatives | 拜尔公开股份有限公司 | 2021-10-26 | — | — | CN | disclosed |