SCHEMBL28644292

SCHEMBL28644292

CNC(=O)C1CCN(C(=O)C(C)Cl)CC1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.61
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61
SMN1; SMN2 Q16637 2/20 0.45
GAA P10253 1/20 0.41
HSD17B10 Q99714 1/20 0.40
CCR1 P32246 1/20 0.38
TRPV1 Q8NER1 3/20 0.38
CYP3A4 P08684 1/20 0.37
CYP2C19 P33261 1/20 0.37
PTPN1 P18031 1/20 0.37
CYP2D6 P10635 1/20 0.36
HRH3 Q9Y5N1 1/20 0.36
BCHE P06276 1/20 0.36
POLB P06746 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28647253 0.90 ALDH1A1 (0.53) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL22917293 0.86 SMN1; SMN2 (0.47) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL28663998 0.82 ALDH1A1 (0.46) ALDH1A1MEN1KMT2ASMN1; SMN2BCHE
SCHEMBL1034955 0.76 SMN1; SMN2 (0.54) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL8351549 0.76 SMN1; SMN2 (0.50) ALDH1A1MEN1KMT2ASMN1; SMN2HSD17B10
SCHEMBL6933685 0.74 ALDH1A1 (0.68) ALDH1A1MEN1KMT2ASMN1; SMN2HSD17B10
SCHEMBL11846880 0.74
SCHEMBL7974782 0.74 SMN1; SMN2 (0.49) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL12026414 0.74 HRH3 (0.46) ALDH1A1MEN1KMT2ASMN1; SMN2GAA
SCHEMBL22481624 0.74 ALDH1A1 (0.59) ALDH1A1MEN1KMT2ASMN1; SMN2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113498342-A Compounds involved in synergistic binding and uses thereof 锐新医药公司 2021-10-12 CN claimed
CN-113498342-A Compounds involved in synergistic binding and uses thereof 锐新医药公司 2021-10-12 CN disclosed