Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PFKFB3 | Q16875 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.42 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.42 |
| ▸ | ACLY | P53396 | 2/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9997760 | 0.79 | ACLY (0.64) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL9997278 | 0.77 | PFKFB3 (0.67) | PFKFB3ALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL9996904 | 0.77 | PFKFB3 (0.74) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL9997485 | 0.76 | GAA (0.69) | PFKFB3ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL9997013 | 0.74 | HSD17B10 (0.67) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL9996868 | 0.74 | PFKFB3 (1.00) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL9996886 | 0.73 | ALDH1A1 (0.74) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL9997407 | 0.72 | HSD17B10 (0.65) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL9997065 | 0.72 | HSD17B10 (0.65) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 | |
| SCHEMBL28636849 | 0.72 | PFKFB3 (0.67) | PFKFB3ALDH1A1HSD17B10HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113396145-A | PFKFB3 inhibitors and uses thereof | 盖罗发现有限责任公司 | 2021-09-14 | — | — | CN | disclosed |