SCHEMBL28644471

SCHEMBL28644471

CCN(CCO)CCCC(C)Nc1ccnc2cc(OC)ccc12

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRA1D P25100 4/20 0.75
CHRM2 P08172 3/20 0.75
CHRM4 P08173 3/20 0.75
CHRM5 P08912 3/20 0.75
ADRA2A P08913 3/20 0.75
CHRM1 P11229 3/20 0.75
ADRA2B P18089 3/20 0.75
ADRA2C P18825 3/20 0.75
CHRM3 P20309 3/20 0.75
KCNH2 Q12809 3/20 0.75
LMNA P02545 3/20 0.75
TMEM97 Q5BJF2 2/20 0.75
SIGMAR1 Q99720 2/20 0.75
ACE2 Q9BYF1 2/20 0.75
CGAS Q8N884 2/20 0.75
TLR9 Q9NR96 1/20 0.75
TLR7 Q9NYK1 1/20 0.75
APP P05067 3/20 0.64
NQO2 P16083 2/20 0.64
CXCR4 P61073 2/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28644469 1.00 ADRA1D (0.75) ADRA1DCHRM2CHRM4CHRM5ADRA2A
SCHEMBL709359 0.87 CHRM2 (0.80) ADRA1DCHRM2CHRM4CHRM5ADRA2A
SCHEMBL19129074 0.87 TMEM97 (0.80) ADRA1DCHRM2CHRM4CHRM5ADRA2A
Hydroxychloroquine SCHEMBL8623049 0.86 CHRM2 (1.00) ADRA1DCHRM2CHRM4CHRM5ADRA2A
Hydroxychloroquine SCHEMBL31023589 0.86 CHRM2 (1.00) ADRA1DCHRM2CHRM4CHRM5ADRA2A
Hydroxychloroquine SCHEMBL30107680 0.86 CHRM2 (1.00) ADRA1DCHRM2CHRM4CHRM5ADRA2A
SCHEMBL1695848 0.86 CHRM2 (0.78) ADRA1DCHRM2CHRM4CHRM5ADRA2A
Hydroxychloroquine SCHEMBL6746375 0.86 CHRM2 (1.00) ADRA1DCHRM2CHRM4CHRM5ADRA2A
Hydroxychloroquine SCHEMBL8170 0.86 CHRM2 (1.00) ADRA1DCHRM2CHRM4CHRM5ADRA2A
Hydroxychloroquine SCHEMBL9047 0.86 CHRM2 (1.00) ADRA1DCHRM2CHRM4CHRM5ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113440528-A Application of optically pure 4-aminoquinoline compound in preparation of drugs for treating coronavirus 上海华理生物医药股份有限公司 2021-09-28 CN disclosed