SCHEMBL709359

SCHEMBL709359

CCN(CCO)CCCC(C)Nc1ccnc2cc(O)ccc12

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.80
CHRM4 P08173 2/20 0.80
CHRM5 P08912 2/20 0.80
ADRA2A P08913 2/20 0.80
CHRM1 P11229 2/20 0.80
ADRA2B P18089 2/20 0.80
ADRA2C P18825 2/20 0.80
CHRM3 P20309 2/20 0.80
KCNH2 Q12809 2/20 0.80
TMEM97 Q5BJF2 2/20 0.80
SIGMAR1 Q99720 2/20 0.80
ACE2 Q9BYF1 2/20 0.80
LMNA P02545 1/20 0.80
ADRA1D P25100 1/20 0.80
CGAS Q8N884 1/20 0.80
TLR9 Q9NR96 1/20 0.80
TLR7 Q9NYK1 1/20 0.80
CYP2D6 P10635 1/20 0.67
CYP2C19 P33261 1/20 0.67
TDP1 Q9NUW8 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL711137 0.94 CHRM2 (0.76) CHRM2CHRM4CHRM5ADRA2ACHRM1
SCHEMBL19129074 0.90 TMEM97 (0.80) CHRM2CHRM4CHRM5ADRA2ACHRM1
Hydroxychloroquine SCHEMBL30107680 0.89 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
Hydroxychloroquine SCHEMBL9047 0.89 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
Hydroxychloroquine SCHEMBL29359553 0.89 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
Hydroxychloroquine SCHEMBL31023589 0.89 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
SCHEMBL1695848 0.89 CHRM2 (0.78) CHRM2CHRM4CHRM5ADRA2ACHRM1
Hydroxychloroquine SCHEMBL8623049 0.89 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
Hydroxychloroquine SCHEMBL8170 0.89 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1
Hydroxychloroquine SCHEMBL6746375 0.89 CHRM2 (1.00) CHRM2CHRM4CHRM5ADRA2ACHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230416786-A1 USE OF AMINOQUINOLINE COMPOUNDS FOR HIGHER GENE INTEGRATION CELLECTIS SA (FR) 2023-12-28 US claimed
EP-4251746-A1 USE OF AMINOQUINOLINE COMPOUNDS FOR HIGHER GENE INTEGRATION Cellectis SA (FR) 2023-10-04 EP claimed
US-20230000893-A1 Antiviral Agents and Nucleoside Analogs for Treatment of Zika Virus UNIV EMORY (US) 2023-01-05 US claimed
WO-2022112596-A1 USE OF AMINOQUINOLINE COMPOUNDS FOR HIGHER GENE INTEGRATION CELLECTIS SA (FR) 2022-06-02 WO claimed
WO-2017165489-A1 ANTIVIRAL AGENTS FOR TREATING ZIKA AND DENGUE VIRUS INFECTIONS EMORY UNIVERSITY (US) 2017-09-28 WO claimed
US-12529056-B2 Compositions and methods of treating facioscapulohumeral muscular dystrophy AVIDITY BIOSCIENCES, INC. (US) 2026-01-20 US disclosed
US-20260014266-A1 COMPOSITIONS AND METHODS OF TREATING MUSCLE DYSTROPHY AVIDITY BIOSCIENCES INC (US) 2026-01-15 US disclosed
US-20260007766-A1 COMPOSITIONS AND METHODS OF TREATING MUSCLE ATROPHY AND MYOTONIC DYSTROPHY AVIDITY BIOSCIENCES, INC. 2026-01-08 US disclosed
US-20250381285-A1 COMPOSITIONS AND METHODS OF TREATING MUSCLE DYSTROPHY AVIDITY BIOSCIENCES INC (US) 2025-12-18 US disclosed
US-20250381286-A1 NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND METHODS OF INDUCING EXON SKIPPING AVIDITY BIOSCIENCES INC (US) 2025-12-18 US disclosed
US-12491257-B2 Compositions and methods of using PRKAG2-targeting antibody-oligonucleotide conjugates AVIDITY BIOSCIENCES, INC. (US) 2025-12-09 US disclosed
EP-4656242-A2 COMPOSITIONS AND METHODS OF TREATING MUSCLE DYSTROPHY Avidity Biosciences, Inc. (US) 2025-12-03 EP disclosed
US-20050124653-A1 Treatment of dna damage related disorders NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2005-06-09 US disclosed
WO-2005016196-A1 COMPOSITIONS AND METHODS FOR DESTABILIZING LYSOSOMES TO INCREASE ONCOGENIC OR ABERRANT PROTEIN DEGRADATION TRUSTEES OF DARTMOUTH COLLEGE (US) 2005-02-24 WO disclosed
US-20050032834-A1 Treatment of DNA damage related disorders ST. JUDE CHILDREN'S RESEARCH HOSPITAL 2005-02-10 US disclosed
US-20050014785-A1 Treatment of radiation disorders PERLEGEN SCIENCES, INC. (US) 2005-01-20 US disclosed
US-20040229908-A1 Compositions and methods for the treatment of Parkinson's disease and tardive dyskinesias Greenlee, Winner and Sullivan, P.C. 2004-11-18 US disclosed
WO-2004050837-A2 TREATMENT OF DNA DAMAGE RELATED DISORDERS ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2004-06-17 WO disclosed
WO-2004050842-A2 ATM KINASE COMPOSITIONS AND METHODS ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2004-06-17 WO disclosed
US-6417177-B1 Chloroquine derivatives for the treatment of Parkinson's disease ALPHA RESEARCH GROUP, LLC 2002-07-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250381286-A1 NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND METHODS OF INDUCING EXON SKIPPING NSUN2, UPF1, SNRPE CHRM2 4848/4885CHRM4 4804/4885CHRM5 4787/4885
US-20050014785-A1 Treatment of radiation disorders XRCC5, XRCC6, QTRT1 CHRM2 4278/4885CHRM4 4731/4885CHRM5 4097/4885
US-20250381285-A1 COMPOSITIONS AND METHODS OF TREATING MUSCLE DYSTROPHY TNNC1, PYGM, MYOF CHRM2 2268/4885CHRM4 3113/4885CHRM5 2993/4885
US-20050124653-A1 Treatment of dna damage related disorders ERCC1, ERCC5, ERCC2 CHRM2 4693/4885CHRM4 4785/4885CHRM5 4531/4885
US-12491257-B2 Compositions and methods of using PRKAG2-targeting antibody-oligonucleotide conjugates PRKCG, PRKAG2, PRKAG1 CHRM2 3492/4885CHRM4 3944/4885CHRM5 3682/4885
US-20260007766-A1 COMPOSITIONS AND METHODS OF TREATING MUSCLE ATROPHY AND MYOTONIC DYSTROPHY MYOF, MTPN, TTN CHRM2 3069/4885CHRM4 3565/4885CHRM5 3442/4885
US-20260014266-A1 COMPOSITIONS AND METHODS OF TREATING MUSCLE DYSTROPHY TNNC1, MYOF, MYH2 CHRM2 2388/4885CHRM4 3970/4885CHRM5 4319/4885
US-20050032834-A1 Treatment of DNA damage related disorders BRCA1, ERCC4, POLN CHRM2 4789/4885CHRM4 4827/4885CHRM5 4815/4885
US-20230000893-A1 Antiviral Agents and Nucleoside Analogs for Treatment of Zika Virus SAMHD1, PNP, NUDT1 CHRM2 3532/4885CHRM4 2569/4885CHRM5 1846/4885
US-20230416786-A1 USE OF AMINOQUINOLINE COMPOUNDS FOR HIGHER GENE INTEGRATION ERCC4, LIG4, LIG3 CHRM2 4834/4885CHRM4 4712/4885CHRM5 4740/4885
US-12529056-B2 Compositions and methods of treating facioscapulohumeral muscular dystrophy UPF1, MYOF, MTPN CHRM2 2998/4885CHRM4 2801/4885CHRM5 3439/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.