Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 2/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | HPGDS | O60760 | 9/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3846380 | 0.87 | ALDH1A1 (0.54) | CBFBCYP11B1CYP11B2PDGFRBPDGFRA | |
| SCHEMBL14756185 | 0.81 | TAAR1 (0.50) | HPGDSPDGFRBPDGFRAMAOBKDM4E | |
| SCHEMBL11971461 | 0.81 | HPGDS (0.56) | CYP11B1CYP11B2HPGDSPDGFRBPDGFRA | |
| SCHEMBL28808959 | 0.79 | HPGDS (0.65) | CYP11B1CYP11B2HPGDSPDGFRBPDGFRA | |
| SCHEMBL14756187 | 0.79 | CHRM2 (0.51) | HPGDSPDGFRBPDGFRAALDH1A1KDM4E | |
| SCHEMBL18572846 | 0.78 | ESR2 (0.54) | CYP11B1CYP11B2HPGDSPDGFRBPDGFRA | |
| SCHEMBL2666094 | 0.77 | PTGS1 (0.62) | CYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL8290192 | 0.76 | HPGDS (0.49) | HPGDSPDGFRBPDGFRAALDH1A1F2 | |
| SCHEMBL15980808 | 0.76 | HPGDS (0.44) | HPGDSPDGFRBPDGFRA | |
| SCHEMBL27947707 | 0.75 | CYP11B1 (0.56) | CYP11B1CYP11B2HPGDSPDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114057815-B | Novel 6-6 bicyclic aromatic ring substituted nucleosides as PRMT5 inhibitors | 詹森药业有限公司 | 2025-02-25 | — | — | CN | disclosed |
| CN-114057815-A | Novel 6-6 bicyclic aromatic ring substituted nucleosides as PRMT5 inhibitors | 詹森药业有限公司 | 2022-02-18 | — | — | CN | disclosed |
| CN-107922413-B | Novel 6-6 bicyclic aromatic ring substituted nucleoside analogs as PRMT5 inhibitors | 詹森药业有限公司 | 2021-10-01 | — | — | CN | disclosed |