SCHEMBL28645554

SCHEMBL28645554

Clc1ccc(Cl)c(C(Cl)(Cl)Cl)c1Cl

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.40
NOTUM Q6P988 2/20 0.39
CYP3A4 P08684 3/20 0.38
MAPK1 P28482 2/20 0.38
LMNA P02545 1/20 0.35
CYP2A6 P11509 3/20 0.33
TDP1 Q9NUW8 2/20 0.33
PNMT P11086 2/20 0.33
CES1 P23141 1/20 0.32
AHR P35869 2/20 0.32
CYP1A2 P05177 3/20 0.30
CYP2D6 P10635 1/20 0.30
NFKB1 P19838 1/20 0.30
TAAR1 Q96RJ0 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10999631 0.83 TSHR (0.46) TSHRNOTUMCYP3A4MAPK1LMNA
SCHEMBL7930064 0.81 TSHR (0.44) TSHRNOTUMCYP3A4MAPK1LMNA
SCHEMBL10493705 0.79 TSHR (0.34) TSHRNOTUMCYP3A4MAPK1LMNA
SCHEMBL10974022 0.76 NOTUM (0.32) TSHRNOTUM
SCHEMBL7932263 0.75 CYP1A2 (0.47) TSHRCYP3A4MAPK1LMNACYP2A6
SCHEMBL27817597 0.74 NOTUM (0.67) NOTUMCYP1A2
SCHEMBL9889139 0.74 NOTUM (0.38) NOTUMCYP3A4MAPK1CYP2A6TDP1
SCHEMBL27779481 0.73 CYP3A4 (0.50) TSHRCYP3A4MAPK1LMNATDP1
SCHEMBL7803577 0.71 TDP1 (0.62) TSHRCYP3A4MAPK1LMNATDP1
SCHEMBL29368277 0.69 CYP3A4 (0.62) TSHRNOTUMCYP3A4MAPK1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113582807-A Method for synthesizing 2, 6-dichlorobenzyl chloride 江苏超跃化学有限公司 2021-11-02 CN disclosed
CN-113582807-A Method for synthesizing 2, 6-dichlorobenzyl chloride 江苏超跃化学有限公司 2021-11-02 CN disclosed