Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30015957 | 1.00 | LMNA (0.43) | LMNAPOLBPTPN1TRPV1SLC6A3 | |
| SCHEMBL24599026 | 0.82 | HDAC1 (0.55) | LMNAPOLBNAMPT | |
| SCHEMBL28632079 | 0.80 | DDR1 (0.45) | LMNAPOLB | |
| SCHEMBL31512899 | 0.80 | TRPV1 (0.50) | LMNAPOLBTRPV1 | |
| SCHEMBL30850105 | 0.80 | CA12 (0.48) | PTPN1TRPV1SCN9AMRGPRX4 | |
| SCHEMBL15600325 | 0.80 | GAA (0.43) | LMNAPOLBTRPV1NAMPTSCN9A | |
| SCHEMBL12322215 | 0.79 | CA12 (0.40) | LMNAPOLBPTPN1TRPV1NAMPT | |
| SCHEMBL20581109 | 0.78 | L3MBTL1 (0.51) | LMNA | |
| SCHEMBL20581110 | 0.78 | L3MBTL1 (0.51) | LMNA | |
| SCHEMBL13701813 | 0.77 | LMNA (0.46) | LMNAPTPN1TRPV1SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113264945-B | Spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| CN-113264945-A | Spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-08-17 | — | — | CN | disclosed |