Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | LCAT | P04180 | 3/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23744764 | 1.00 | EIF2AK4 (0.39) | EIF2AK4CHRM4CHRM2CHRM1CHRM3 | |
| SCHEMBL20555984 | 1.00 | EIF2AK4 (0.39) | EIF2AK4CHRM4CHRM2CHRM1CHRM3 | |
| SCHEMBL15203482 | 0.80 | DHFR (0.45) | EIF2AK4CHRM4CHRM2CHRNB4CHRNA3 | |
| SCHEMBL23561115 | 0.79 | TGFBR1 (0.39) | CHRNB4CHRNA3 | |
| SCHEMBL26088929 | 0.74 | CHRM4 (0.53) | CHRM4CHRM2CHRM1CHRM3CHRM5 | |
| SCHEMBL23727544 | 0.73 | EIF2AK4 (0.44) | EIF2AK4CHRM4CHRM2CHRM1 | |
| SCHEMBL18825871 | 0.73 | EIF2AK4 (0.44) | EIF2AK4CHRM4CHRM2CHRM1 | |
| SCHEMBL20555935 | 0.73 | CHRM2 (0.44) | CHRM4CHRM2CHRM1CHRM3CHRM5 | |
| SCHEMBL23728111 | 0.72 | NOTUM (0.45) | EIF2AK4CHRNB4CHRNA3 | |
| SCHEMBL17513742 | 0.72 | NOTUM (0.45) | EIF2AK4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371164-B1 | N-[2-(1-BENZYLPIPERIDIN-4-YL)ETHYL]-4-(PYRAZIN-2-YL)-PIPERAZINE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MUSCARINIC RECEPTOR 4 (M4) ANTAGONISTS FOR TREATING NEUROLOGICAL DISEASES | NEUROCRINE BIOSCIENCES INC (US) | 2022-03-16 | — | — | EP | disclosed |
| CN-108349936-B | Compounds as muscarinic receptor 4 antagonists | 纽罗克里生物科学有限公司 | 2021-10-01 | — | — | CN | disclosed |