Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 11/20 | 0.45 |
| ▸ | BTK | Q06187 | 2/20 | 0.45 |
| ▸ | BLK | P51451 | 1/20 | 0.45 |
| ▸ | BMX | P51813 | 1/20 | 0.45 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.45 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | ABL2 | P42684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28859066 | 0.88 | BTK (0.58) | EGFRERBB2BTKBLKBMX | |
| SCHEMBL29989719 | 0.87 | BTK (0.46) | EGFRERBB2BTKBLKBMX | |
| SCHEMBL28645870 | 0.87 | BTK (0.46) | EGFRERBB2BTKBLKBMX | |
| SCHEMBL28925175 | 0.85 | KDM1A (0.43) | EGFRERBB2BTKBLKBMX | |
| SCHEMBL29989219 | 0.80 | SLC6A4 (0.40) | EGFRERBB2BTKBLKBMX | |
| SCHEMBL28645873 | 0.80 | SLC6A4 (0.40) | EGFRERBB2BTKBLKBMX | |
| SCHEMBL28636590 | 0.80 | KDM1A (0.38) | EGFRERBB2BTKBLKBMX | |
| SCHEMBL29989351 | 0.79 | BTK (0.48) | EGFRERBB2BTKBLKBMX | |
| SCHEMBL21044817 | 0.79 | BTK (0.53) | BTK | |
| SCHEMBL28636595 | 0.78 | BTK (0.45) | EGFRERBB2BTKBLKBMX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113493439-B | Substituted acrylamide derivative, composition and application thereof | 深圳市塔吉瑞生物医药有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-113493439-A | Substituted acrylamide derivative, composition and application thereof | 深圳市塔吉瑞生物医药有限公司 | 2021-10-12 | — | — | CN | disclosed |