Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.45 |
| ▸ | MAP3K5 | Q99683 | 16/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28648560 | 0.87 | GRM5 (0.44) | GRM5GRM1MAP3K5MAPT | |
| SCHEMBL28663394 | 0.87 | MAP3K5 (0.46) | GRM5GRM1MAP3K5RIPK2TSHR | |
| SCHEMBL28648131 | 0.86 | MAP3K5 (0.44) | MAP3K5RIPK2 | |
| SCHEMBL28660344 | 0.85 | MAP3K5 (0.43) | MAP3K5RIPK2 | |
| SCHEMBL20672216 | 0.80 | MAP3K5 (0.43) | GRM5GRM1MAP3K5RIPK2ALOX15 | |
| SCHEMBL30028786 | 0.80 | MAP3K5 (0.43) | GRM5GRM1MAP3K5RIPK2ALOX15 | |
| SCHEMBL28643803 | 0.80 | MAP3K5 (0.53) | GRM5GRM1MAP3K5MAPT | |
| SCHEMBL21461103 | 0.80 | MAP3K5 (0.52) | GRM5GRM1MAP3K5 | |
| SCHEMBL28656996 | 0.79 | MAP3K5 (0.53) | GRM5GRM1MAP3K5RIPK2 | |
| SCHEMBL234409 | 0.79 | MAP3K5 (0.43) | GRM5GRM1MAP3K5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109400625-B | Fused bicyclic compound and application thereof in medicine | 广东东阳光药业有限公司 | 2021-11-12 | — | — | CN | disclosed |