Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 4/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28653697 | 0.91 | MAPT (0.39) | CYP1A2CYP3A4CYP2C19MAPTMAPK1 | |
| SCHEMBL28670348 | 0.86 | CYP1A2 (0.36) | CYP1A2CYP3A4CYP2C19MAPTMAPK1 | |
| SCHEMBL28650491 | 0.85 | CYP1A2 (0.36) | CYP1A2CYP3A4CYP2C19MAPTMAPK1 | |
| SCHEMBL30888425 | 0.82 | RAPGEF4 (0.33) | MEN1KMT2ARAPGEF4F2PRSS1 | |
| SCHEMBL28658591 | 0.81 | CYP1A2 (0.40) | CYP1A2CYP3A4CYP2C19MAPTMAPK1 | |
| SCHEMBL20636696 | 0.77 | MAPK1 (0.42) | CYP1A2CYP3A4CYP2C19MAPTMAPK1 | |
| SCHEMBL12539750 | 0.76 | CYP1A2 (0.43) | CYP1A2CYP3A4CYP2C19MAPTMAPK1 | |
| SCHEMBL14810409 | 0.74 | RAPGEF4 (0.36) | CYP1A2CYP3A4CYP2C19MAPTMAPK1 | |
| SCHEMBL30888458 | 0.73 | RAPGEF4 (0.33) | MAPK1RAPGEF4F2PRSS1PRSS2 | |
| SCHEMBL30888439 | 0.72 | RAPGEF4 (0.34) | MAPTMAPK1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109963851-B | Fused bicyclic pyridine compounds and their use as AMPA receptor modulators | 詹森药业有限公司 | 2021-11-30 | — | — | CN | disclosed |