Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
| ▸ | TYK2 | P29597 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.53 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.53 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194694 | 0.89 | GRM5 (0.65) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL28576479 | 0.86 | KMT2A (0.55) | JAK2TYK2NPC1RAB9AKMT2A | |
| SCHEMBL11483728 | 0.84 | GRM4 (0.63) | NPC1RAB9AMAPTNPSR1GRM5 | |
| SCHEMBL30600561 | 0.84 | SMN1; SMN2 (0.67) | NPC1RAB9AKMT2AMEN1GRM5 | |
| SCHEMBL7669653 | 0.83 | RAB9A (0.64) | JAK2TYK2NPC1RAB9AATM | |
| SCHEMBL29409167 | 0.82 | RAB9A (0.62) | JAK2TYK2NPC1RAB9AATM | |
| SCHEMBL1569099 | 0.82 | RAB9A (0.62) | JAK2TYK2NPC1RAB9AATM | |
| SCHEMBL17539392 | 0.82 | KMT2A (0.51) | JAK2TYK2NPC1RAB9AMAPT | |
| SCHEMBL21903652 | 0.82 | KMT2A (0.51) | JAK2TYK2NPC1RAB9AKMT2A | |
| SCHEMBL2762187 | 0.81 | MAPT (0.55) | NPC1RAB9AMAPTNPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4006035-B1 | QUINAZOLINE DERIVATIVES AS TYROSINE KINASE INHIBITORS FOR THE TREATMENT OF CANCER | NEUPHARMA INC (US) | 2023-11-22 | — | — | EP | disclosed |
| CN-113735850-A | Synthesis method of 1,2, 4-triazole compound | 河南师范大学 | 2021-12-03 | — | — | CN | disclosed |