Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL744322 | 0.71 | ACHE (0.44) | KDM4EMAPTCYP3A4HPGDGAA | |
| SCHEMBL2302753 | 0.70 | ACHE (0.38) | MAPTCYP3A4CA9KMT2AACHE | |
| SCHEMBL8330318 | 0.70 | POLB (0.53) | POLBKDM4EMAPTCYP3A4HPGD | |
| Methyl 2,4,6-Trimethoxybenzoate SCHEMBL2563067 | 0.70 | CYP3A4 (0.58) | KDM4ECYP3A4HPGDUSP2GAA | |
| SCHEMBL6380548 | 0.69 | KDM4E (0.46) | POLBKDM4EMAPTCYP3A4HPGD | |
| SCHEMBL24169438 | 0.68 | KDM4E (0.44) | POLBKDM4EMAPTCYP3A4HPGD | |
| SCHEMBL26604916 | 0.68 | GAA (0.47) | POLBKDM4EMAPTCYP3A4HPGD | |
| SCHEMBL21616730 | 0.68 | ERN1 (0.46) | POLBKDM4EMAPTCYP3A4HPGD | |
| SCHEMBL2828160 | 0.68 | GAA (0.32) | KDM4EMAPTCYP3A4HPGDGAA | |
| SCHEMBL14384290 | 0.68 | KDM4E (0.53) | POLBKDM4EMAPTCYP3A4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2543390-A1 | Pharmaceutical composition | Kyowa Hakko Kirin Co., Ltd. (JP) | 2013-01-09 | — | — | EP | claimed |
| US-20100098690-A1 | PHARMACEUTICAL COMPOSITION | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-04-22 | — | — | US | claimed |
| EP-2133094-A1 | PHARMACEUTICAL COMPOSITION | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-12-16 | — | — | EP | claimed |
| US-20090042883-A1 | ANTITUMOR AGENT | KYOWA HAKKOKOGYO CO. (JP) | 2009-02-12 | — | — | US | claimed |
| CN-101123954-A | Antitumor agent | KYOWA HAKKO KOGYO KK (JP) | 2008-02-13 | — | — | CN | claimed |
| EP-1852112-A1 | ANTI-TUMOR AGENT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-11-07 | — | — | EP | claimed |
| US-20070032532-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-02-08 | — | — | US | claimed |
| CN-1791568-A | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO KK (JP) | 2006-06-21 | — | — | CN | claimed |
| EP-1642880-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-04-05 | — | — | EP | claimed |
| EP-2543390-A1 | Pharmaceutical composition | Kyowa Hakko Kirin Co., Ltd. (JP) | 2013-01-09 | — | — | EP | disclosed |
| CN-101123954-B | ANTITUMOR AGENT | KYOWA HAKKO KOGYO KK | 2011-07-13 | — | — | CN | disclosed |
| US-7767693-B2 | Hsp90 family protein inhibitors | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-08-03 | — | — | US | disclosed |
| US-20100104567-A1 | PHARMACEUTICAL COMPOSITION | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-04-29 | — | — | US | disclosed |
| US-20100098690-A1 | PHARMACEUTICAL COMPOSITION | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-04-22 | — | — | US | disclosed |
| US-20090042883-A1 | ANTITUMOR AGENT | KYOWA HAKKOKOGYO CO. (JP) | 2009-02-12 | — | — | US | disclosed |
| CN-101123954-A | Antitumor agent | KYOWA HAKKO KOGYO KK (JP) | 2008-02-13 | — | — | CN | disclosed |
| EP-1852112-A1 | ANTI-TUMOR AGENT | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-11-07 | — | — | EP | disclosed |
| US-20070032532-A1 | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-02-08 | — | — | US | disclosed |
| CN-1791568-A | Hsp90 family protein inhibitors | KYOWA HAKKO KOGYO KK (JP) | 2006-06-21 | — | — | CN | disclosed |
| EP-1642880-A1 | HSP90 FAMILY PROTEIN INHIBITORS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-04-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032532-A1 | Hsp90 family protein inhibitors | HSP90AB1, HSP90B1, HSP90AB2P | POLB 4195/4885KDM4E 2968/4885MAPT 1791/4885 |
| US-20090042883-A1 | ANTITUMOR AGENT | MCL1, HDAC7, TP53 | POLB 3104/4885KDM4E 2024/4885MAPT 4878/4885 |
| US-20100104567-A1 | PHARMACEUTICAL COMPOSITION | FLT4, FLT3, FLT1 | POLB 1165/4885KDM4E 907/4885MAPT 2970/4885 |
| US-20100098690-A1 | PHARMACEUTICAL COMPOSITION | HSP90B1, HSP90AB1, HSP90AB2P | POLB 4356/4885KDM4E 3110/4885MAPT 1634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.