Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28650857 | 1.00 | VCP (0.47) | VCPNPSR1AKR1C3MCL1RECQL | |
| SCHEMBL28650939 | 0.91 | VCP (0.58) | VCPNPSR1AKR1C3ALDH1A1FFAR1 | |
| SCHEMBL28650938 | 0.91 | VCP (0.58) | VCPNPSR1AKR1C3ALDH1A1FFAR1 | |
| SCHEMBL28657828 | 0.89 | MEN1 (0.45) | VCPNPSR1ALDH1A1FFAR1KMT2A | |
| SCHEMBL28657829 | 0.89 | MEN1 (0.45) | VCPNPSR1ALDH1A1FFAR1KMT2A | |
| SCHEMBL7659428 | 0.82 | AKR1C3 (0.53) | AKR1C3MCL1RECQLALDH1A1TSHR | |
| SCHEMBL28647750 | 0.81 | ALDH1A1 (0.55) | VCPNPSR1MCL1ALDH1A1FFAR1 | |
| SCHEMBL28647747 | 0.81 | ALDH1A1 (0.55) | VCPNPSR1MCL1ALDH1A1FFAR1 | |
| SCHEMBL28650155 | 0.80 | SMN1; SMN2 (0.44) | VCPNPSR1AKR1C3MCL1RECQL | |
| SCHEMBL6344582 | 0.77 | MCL1 (0.68) | AKR1C3MCL1ALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113651755-B | 4-azafluorene compound and preparation method and application thereof | 山东师范大学 | 2022-07-29 | — | — | CN | claimed |
| CN-113651755-A | 4-azafluorene compound and preparation method and application thereof | 山东师范大学 | 2021-11-16 | — | — | CN | claimed |
| CN-113651755-B | 4-azafluorene compound and preparation method and application thereof | 山东师范大学 | 2022-07-29 | — | — | CN | disclosed |
| CN-113651755-A | 4-azafluorene compound and preparation method and application thereof | 山东师范大学 | 2021-11-16 | — | — | CN | disclosed |