Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SIK1 | P57059 | 1/20 | 0.38 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.38 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL234409 | 0.89 | MAP3K5 (0.43) | MAP3K5MAPTABL1GRM5GRM1 | |
| SCHEMBL28648560 | 0.88 | GRM5 (0.44) | MAP3K5MAPTTP53KMT2AABL1 | |
| SCHEMBL28643811 | 0.88 | MAP3K5 (0.43) | MAP3K5MAPTTP53ABL1GRM5 | |
| SCHEMBL233653 | 0.84 | MAP3K5 (0.44) | MAP3K5MAPTABL1 | |
| SCHEMBL28643381 | 0.79 | MAPK1 (0.43) | MAP3K5ABL1PDE4APDE4BPDE4C | |
| SCHEMBL28649130 | 0.78 | GRM5 (0.45) | MAP3K5MAPTGRM5GRM1 | |
| SCHEMBL28538145 | 0.77 | MAP3K5 (0.41) | MAP3K5GRM5GRM1 | |
| SCHEMBL28663394 | 0.77 | MAP3K5 (0.46) | MAP3K5GRM5GRM1 | |
| SCHEMBL28648131 | 0.76 | MAP3K5 (0.44) | MAP3K5 | |
| SCHEMBL28663432 | 0.75 | MAP3K5 (0.41) | MAP3K5PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109400625-B | Fused bicyclic compound and application thereof in medicine | 广东东阳光药业有限公司 | 2021-11-12 | — | — | CN | disclosed |