Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 2/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21937607 | 0.88 | GRM5 (0.42) | GPR119TSHRALOX15STSGPR183 | |
| SCHEMBL28661875 | 0.87 | GRM5 (0.46) | GPR119TACR1GPR183USP30GRM5 | |
| SCHEMBL31556485 | 0.86 | MAPT (0.48) | GPR119STSTACR1GPR183 | |
| SCHEMBL5237125 | 0.85 | GRM5 (0.47) | GPR119TSHRALOX15ATMOPRD1 | |
| SCHEMBL28643218 | 0.83 | GPR119 (0.41) | GPR119OPRD1OPRK1GPR183 | |
| SCHEMBL28646247 | 0.83 | GRM5 (0.57) | GPR119TSHRALOX15ATMOPRD1 | |
| SCHEMBL31134174 | 0.81 | GPR119 (0.46) | GPR119OPRD1OPRK1GPR183 | |
| SCHEMBL28653874 | 0.81 | GPR119 (0.46) | GPR119OPRD1OPRK1GPR183 | |
| SCHEMBL23250136 | 0.81 | USP30 (0.48) | GPR119TSHRALOX15ATMOPRD1 | |
| Trifluoroacetic Acid SCHEMBL30835943 | 0.80 | MAPT (0.41) | GPR119STSTACR1GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113620945-B | RET inhibitor, pharmaceutical composition thereof and application of RET inhibitor in medicines | 广东东阳光药业股份有限公司 | 2024-08-23 | — | — | CN | disclosed |
| CN-113620945-A | RET inhibitor, pharmaceutical composition thereof and application thereof in medicines | 广东东阳光药业有限公司 | 2021-11-09 | — | — | CN | disclosed |