Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 5/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 3/20 | 0.42 |
| ▸ | ALPL | P05186 | 3/20 | 0.41 |
| ▸ | ALPG | P10696 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28669425 | 0.89 | HPGD (0.53) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL28655968 | 0.84 | KMT2A (0.58) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL28669731 | 0.84 | MAPK1 (0.60) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL24029051 | 0.82 | MEN1 (0.53) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL24029052 | 0.82 | MEN1 (0.53) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL24019625 | 0.82 | MEN1 (0.53) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL28661287 | 0.82 | ALDH1A1 (0.47) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL28660621 | 0.81 | SMN1; SMN2 (0.58) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL21952091 | 0.81 | MAPT (0.60) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL31396323 | 0.81 | MAPT (0.60) | HPGDKMT2AMEN1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115768422-A | Ubiquitin ligase inhibitors for the treatment of cancer | 诺沃亚桑托斯教授基金会 | 2023-03-07 | — | — | CN | disclosed |
| CN-113677340-A | Compounds that selectively and efficiently inhibit Hakai-mediated ubiquitination as anti-cancer agents | 诺沃亚桑托斯教授基金会 | 2021-11-19 | — | — | CN | disclosed |