Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | GSK3B | P49841 | 1/20 | 0.56 |
| ▸ | MMP1 | P03956 | 1/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2865544 | 0.92 | MAPT (0.65) | ALDH1A1MAPTPTPN1GSK3BMMP1 | |
| SCHEMBL2749609 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MAPTPTPN1GSK3BMMP1 | |
| SCHEMBL18329404 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTPTPN1GSK3BMMP1 | |
| SCHEMBL20355706 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPTPTPN1GSK3BMMP1 | |
| SCHEMBL1349394 | 0.80 | PTPN1 (0.57) | ALDH1A1MAPTPTPN1GSK3BMMP1 | |
| SCHEMBL11686883 | 0.79 | MAPT (0.58) | ALDH1A1MAPTPTPN1GSK3BMMP1 | |
| SCHEMBL29987081 | 0.79 | PTPN1 (0.75) | ALDH1A1MAPTPTPN1GSK3BMMP1 | |
| SCHEMBL13731810 | 0.79 | ALDH1A1 (0.61) | ALDH1A1MAPTPTPN1GSK3BMMP1 | |
| SCHEMBL13731809 | 0.79 | ALDH1A1 (0.61) | ALDH1A1MAPTPTPN1GSK3BMMP1 | |
| SCHEMBL3391803 | 0.79 | ALDH1A1 (0.60) | ALDH1A1MAPTPTPN1GSK3BMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805141-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2010-01-20 | — | — | EP | disclosed |