Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3320943 | 0.88 | ALDH1A1 (0.56) | ALDH1A1MAPTPTPN1GSK3BCES2 | |
| SCHEMBL5789171 | 0.83 | ALDH1A1 (0.62) | ALDH1A1MAPTHDAC1SRD5A2HTT | |
| SCHEMBL22118738 | 0.81 | ALDH1A1 (0.47) | ALDH1A1MAPTPTPN1GSK3BHDAC1 | |
| SCHEMBL31423428 | 0.81 | PTPN1 (0.59) | ALDH1A1MAPTPTPN1GSK3BCES2 | |
| SCHEMBL830420 | 0.80 | PTPN1 (0.62) | ALDH1A1MAPTPTPN1GSK3BCES2 | |
| SCHEMBL2542330 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPTPTPN1GSK3BCES2 | |
| SCHEMBL5369280 | 0.80 | CES2 (0.59) | ALDH1A1CES2HDAC1SRD5A2KMT2A | |
| SCHEMBL27743871 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MAPTPTPN1GSK3BCES2 | |
| SCHEMBL29200055 | 0.79 | PTPN1 (0.56) | ALDH1A1MAPTPTPN1GSK3BCES2 | |
| SCHEMBL7847608 | 0.79 | PTPN1 (0.60) | ALDH1A1MAPTPTPN1GSK3BCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249411-A1 | Stereoselective Alkylation of Chiral 2-Methly-4 Protected Piperazines | WU WENXUE | 2010-09-30 | — | — | US | claimed |
| EP-2141143-A2 | Stereoselective alkylation of chiral 2-methyl-4 protected piperazines | SCHERING CORPORATION (US) | 2010-01-06 | — | — | EP | claimed |
| US-20050171120-A1 | Stereoselective alkylation of chiral 2-methyl-4-protected piperazines | WU WENXUE (US) | 2005-08-04 | — | — | US | claimed |
| CN-1642930-A | Stereoselective alkylation of chiral 2-methyl-4-protected piperazines | SCHERING CORP (US) | 2005-07-20 | — | — | CN | claimed |
| EP-1490346-A2 | STEREOSELECTIVE ALKYLATION OF CHIRAL 2-METHYL-4-PROTECTED PIPERAZINES | SCHERING CORPORATION (US) | 2004-12-29 | — | — | EP | claimed |
| US-20030208074-A1 | Stereoselective alkylation of chiral 2-methyl-4-protected piperazines | SCHERING CORPORATION | 2003-11-06 | — | — | US | claimed |
| WO-2003084942-A2 | STEREOSELECTIVE ALKYLATION OF CHIRAL 2-METHYL-4-PROTECTED PIPERAZINES | SCHERING CORPORATION (US) | 2003-10-16 | — | — | WO | claimed |
| EP-3302484-B1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-3302484-B1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-09-16 | — | — | EP | disclosed |
| US-10160762-B2 | 6-alkyl dihydropyrazolopyrimidinone compounds as PDE2 inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-12-25 | — | — | US | disclosed |
| US-10017508-B2 | Nitrogenated heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-07-10 | — | — | US | disclosed |
| US-20180134712-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180134712-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-17 | — | — | US | disclosed |
| EP-1546126-A1 | PROCESS FOR PRODUCING TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE DERIVATIVES | Central Glass Company, Limited (JP) | 2005-06-29 | — | — | EP | disclosed |
| US-6872826-B2 | Stereoselective alkylation of chiral 2-methyl-4-protected piperazines | SCHERING CORPORATION (US) | 2005-03-29 | — | — | US | disclosed |
| EP-1490346-A2 | STEREOSELECTIVE ALKYLATION OF CHIRAL 2-METHYL-4-PROTECTED PIPERAZINES | SCHERING CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| JP-2004254554-A | METHOD OF PRODUCING OPTICALLY ACTIVE 2-METHOXY-1-(4-TRIFLUOROMETHYL-PHENYL)ETHANOL | MITSUBISHI CHEMICALS CORP | 2004-09-16 | — | — | JP | disclosed |
| WO-2004014887-A1 | PROCESS FOR PRODUCING TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE DERIVATIVES | CENTRAL GLASS COMPANY, LIMITED (JP) | 2004-02-19 | — | — | WO | disclosed |
| US-20030208074-A1 | Stereoselective alkylation of chiral 2-methyl-4-protected piperazines | SCHERING CORPORATION | 2003-11-06 | — | — | US | disclosed |
| WO-2003084942-A2 | STEREOSELECTIVE ALKYLATION OF CHIRAL 2-METHYL-4-PROTECTED PIPERAZINES | SCHERING CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10160762-B2 | 6-alkyl dihydropyrazolopyrimidinone compounds as PDE2 inhibitors | PDE12, PDE2A, PDE4D | ALDH1A1 705/4885MAPT 662/4885PTPN1 1350/4885 |
| US-20180134712-A1 | 6-ALKYL DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | PDE12, PDE2A, PDE4D | ALDH1A1 705/4885MAPT 662/4885PTPN1 1350/4885 |
| US-20050171120-A1 | Stereoselective alkylation of chiral 2-methyl-4-protected piperazines | AZI2, ALKBH5, DNMT1 | ALDH1A1 578/4885MAPT 3482/4885PTPN1 4128/4885 |
| US-20030208074-A1 | Stereoselective alkylation of chiral 2-methyl-4-protected piperazines | AZI2, DNMT1, ALKBH5 | ALDH1A1 492/4885MAPT 3312/4885PTPN1 4028/4885 |
| US-20100249411-A1 | Stereoselective Alkylation of Chiral 2-Methly-4 Protected Piperazines | ALKBH5, AZI2, PNMT | ALDH1A1 449/4885MAPT 3509/4885PTPN1 3440/4885 |
| US-10017508-B2 | Nitrogenated heterocyclic compound | PDE2A, PDE5A, PDE3A | ALDH1A1 492/4885MAPT 487/4885PTPN1 227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.