Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 2/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.40 |
| ▸ | PHGDH | O43175 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | YES1 | P07947 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28655966 | 0.88 | HRH4 (0.50) | NPC1RAB9AMAPTPDE10AHRH4 | |
| SCHEMBL28659509 | 0.88 | CHRNB2 (0.54) | MAPK1TDP1HRH4CHEK1KDM4E | |
| SCHEMBL28654900 | 0.88 | CHEK1 (0.54) | MAPK1TDP1HRH4CHEK1KDM4E | |
| SCHEMBL28672733 | 0.88 | MAPT (0.51) | NPC1RAB9AMAPTPDE10ACHEK1 | |
| SCHEMBL28677765 | 0.88 | HRH4 (0.51) | NPC1RAB9AMAPTTDP1PHGDH | |
| SCHEMBL28654946 | 0.84 | HRH4 (0.49) | PDE10AHRH4PIM1 | |
| SCHEMBL28654943 | 0.84 | HRH4 (0.49) | PDE10AHRH4PIM1 | |
| SCHEMBL28677837 | 0.84 | HRH4 (0.49) | PDE10AHRH4PIM1 | |
| SCHEMBL28660326 | 0.81 | HRH4 (0.54) | PDE10AHRH4PIM1 | |
| SCHEMBL28668848 | 0.81 | HRH4 (0.54) | PDE10AHRH4PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113717158-A | 2- (N- (pyridine-2-yl) amino) quinoline derivative and application thereof | 河南省人民医院 | 2021-11-30 | — | — | CN | claimed |
| CN-113717158-A | 2- (N- (pyridine-2-yl) amino) quinoline derivative and application thereof | 河南省人民医院 | 2021-11-30 | — | — | CN | disclosed |