Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 2/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.47 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28655646 | 0.88 | MAPK1 (0.44) | MAPTKDM4ENPC1GAARAB9A | |
| SCHEMBL28654900 | 0.85 | CHEK1 (0.54) | KDM4ECHEK1KDM1AALDH1A1 | |
| SCHEMBL28677765 | 0.85 | HRH4 (0.51) | MAPTKDM4ENPC1GAARAB9A | |
| SCHEMBL28659509 | 0.81 | CHRNB2 (0.54) | KDM4ECHEK1ALDH1A1 | |
| SCHEMBL28655966 | 0.81 | HRH4 (0.50) | MAPTKDM4ENPC1GAARAB9A | |
| SCHEMBL28660329 | 0.79 | HRH4 (0.54) | PDE10A | |
| SCHEMBL28668848 | 0.79 | HRH4 (0.54) | PDE10A | |
| SCHEMBL28660326 | 0.79 | HRH4 (0.54) | PDE10A | |
| SCHEMBL28654943 | 0.78 | HRH4 (0.49) | PDE10A | |
| SCHEMBL25769210 | 0.76 | CHEK1 (0.53) | MAPTNPC1GAARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113717158-A | 2- (N- (pyridine-2-yl) amino) quinoline derivative and application thereof | 河南省人民医院 | 2021-11-30 | — | — | CN | claimed |
| CN-113717158-A | 2- (N- (pyridine-2-yl) amino) quinoline derivative and application thereof | 河南省人民医院 | 2021-11-30 | — | — | CN | disclosed |