Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 3/20 | 0.34 |
| ▸ | BCOR | Q6W2J9 | 3/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | TLR3 | O15455 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19030546 | 0.83 | IRAK4 (0.46) | BCL6BCORIRAK4MEN1KMT2A | |
| SCHEMBL19030117 | 0.79 | IRAK4 (0.34) | BCL6BCORIRAK4MEN1KMT2A | |
| SCHEMBL19030116 | 0.79 | IRAK4 (0.34) | BCL6BCORIRAK4MEN1KMT2A | |
| SCHEMBL19030181 | 0.78 | IRAK4 (0.37) | BCL6BCORIRAK4MEN1KMT2A | |
| SCHEMBL19030139 | 0.76 | SIRT6 (0.40) | IRAK4MEN1KMT2A | |
| SCHEMBL19046170 | 0.75 | PDE4B (0.39) | IRAK4 | |
| SCHEMBL28668729 | 0.75 | PDE4B (0.39) | IRAK4 | |
| SCHEMBL19030656 | 0.75 | IRAK4 (0.38) | IRAK4MEN1KMT2AALK | |
| SCHEMBL19030657 | 0.75 | IRAK4 (0.38) | IRAK4MEN1KMT2AALK | |
| SCHEMBL19030287 | 0.72 | IRAK4 (0.55) | IRAK4MEN1KMT2AALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108473498-B | Pyrazolo [1,5a ] pyrimidine derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2021-11-02 | — | — | CN | disclosed |