Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 4/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20088555 | 0.84 | KDM4E (0.36) | PDE10AHTTALDH1A1KMT2A | |
| SCHEMBL20094623 | 0.78 | PDE10A (0.41) | PDE10ALRRK2HTT | |
| SCHEMBL20088552 | 0.76 | PDE10A (0.45) | PDE10A | |
| SCHEMBL20106759 | 0.75 | KDM4E (0.34) | HTTALDH1A1KMT2A | |
| SCHEMBL20094260 | 0.71 | ALDH1A1 (0.37) | NOTUMSMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL20094293 | 0.71 | TRPA1 (0.37) | — | |
| SCHEMBL20088561 | 0.69 | PDE10A (0.38) | PDE10AHTTKMT2A | |
| SCHEMBL20088554 | 0.68 | KDM4E (0.33) | HTTALDH1A1KMT2A | |
| SCHEMBL22368275 | 0.67 | ALDH1A1 (0.38) | PDE10AHTTALDH1A1KMT2A | |
| SCHEMBL20088542 | 0.65 | ALDH1A1 (0.30) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109963851-B | Fused bicyclic pyridine compounds and their use as AMPA receptor modulators | 詹森药业有限公司 | 2021-11-30 | — | — | CN | disclosed |